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. Author manuscript; available in PMC: 2012 Oct 22.
Published in final edited form as: Mol Cell Endocrinol. 2011 Jun 1;346(1-2):102–109. doi: 10.1016/j.mce.2011.05.041

Figure 4.

Figure 4

An IGD pedigree showcasing autosomal dominant inheritance with variable expressivity. As is typical for an autosomal dominant inheritance pattern, several generations have an “affected” family member. Affected individuals have one wild-type FGFR1 allele and one mutated FGFR1 allele. Additionally, the concept of variable expressivity is shown by the grandmother with delayed puberty, the mother with anosmia and normal puberty, and the proband (indicated by the arrow) with IGD, anosmia, and cleft lip, though all have the same genetic change.