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. Author manuscript; available in PMC: 2012 Oct 3.
Published in final edited form as: Mol Pharm. 2011 Aug 17;8(5):1941–1954. doi: 10.1021/mp200309x

Figure 11.

Figure 11

Differential scanning calorimetry of the unmodified 15-bp duplex and duplexes containing a single, monofunctional adduct of 1 or 2. A. Nucleotide sequence of the 15-bp duplex; the bold letter (central G residue) in the top strand indicates the location of the monofunctional adduct of the platinum complex. B. DSC thermograms; lines: solid, unmodified duplex; dashed, duplex containing the adduct of 1; dotted, duplex containing the adduct of 2. The duplex concentration was 30 μM, and the buffer conditions were 10 mM phosphate buffer (pH 7) plus 150 mM NaCl. For other details, see the text.