Table 1.

Chemical structures of acridinones studied

Compound	X	n	R 1	R 2	R 3	R 4	R 5	R 6	ILSa	ΔT m b
C-1310	C	2	CH2CH3	CH2CH3	OH	H	CH3	H	185	15.3
C-1311	C	2	CH2CH3	CH2CH3	OH	H	H	H	93	13.7
C-1330	C	2	CH2CH3	CH2CH3	OCH3	H	H	H	96	11.5
C-1415	C	2	CH2CH3	CH2CH3	H	H	H	H	55	7.2
C-1419	C	2	CH2CH3	CH2CH3	H	H	H	OH	27	8.3
C-1558	C	2	CH2CH3	CH2CH3	C(CH3)3	H	H	H	0	2.4
C-1176	C	2	CH3	CH3	H	H	H	H	90	9.5
C-1263	C	2	CH3	CH3	OH	H	H	H	110	12.3
C-1212	C	3	CH3	CH3	H	H	H	H	25	11.5
C-1371	C	3	CH3	CH3	OH	H	H	H	120	3.5
C-1554	C	5	CH2CH3	CH2CH3	CH3	H	H	H	20	10.5
C-1266	C	5	CH3	CH3	H	H	H	H	10	9.9
C-1492	C	5	CH3	CH3	OH	H	H	H	85	13.1
C-1233	N	2	CH3	CH3	H	H	–	H	77	9.1
C-1303	N	2	CH3	CH3	OH	H	–	H	102	13.1
C-1533	N	2	CH3	CH3	OH	CH3	–	H	10	8.1
C-1567	N	2	CH3	CH3	C(CH3)3	H	–	H	0	6.8
C-1410	N	2	H	CH2CH3	OH	H	–	H	78	7.1
C-1296	N	3	CH3	CH3	CH3	H	–	H	18	11.5
C-1305	N	3	CH3	CH3	OH	H	–	H	165	15.1

^aThe percentage of increase in survival time of treated to control mice with P388 leukemia at optimal dose

^bThe increase in DNA melting temperature (expressed in centigrade degrees) at drug to DNA base pairs 0.25 M ratio