Table 2.
Age Differences in Clinical Complications and Short-term Mortality in Patients Hospitalized with Acute Myocardial Infarction
| Men |
Women |
|||||||
|---|---|---|---|---|---|---|---|---|
| <65 y | 65–74 y | ≥75 y | P value† |
<65 y | 65–74 y | ≥75 y | P value† |
|
| Atrial fibrillation | ||||||||
| Events, n (%) | 185(7.4) | 226(16.1) | 325(21.7) | 68(8.1) | 141(13.9) | 451(21.7) | ||
| Crude OR (95% CI) | Referent | NA* | NA | 0.12 | Referent | 1.79(1.31–2.42) | 3.17(2.42–4.15) | 0.60 |
| Adjusted OR (95% CI) | Referent | NA | NA | 0.04 | Referent | 1.74(1.25–2.43) | 3.09(2.27–4.21) | 0.40 |
| Heart failure | ||||||||
| Events, n (%) | 414(17.3) | 381(29.8) | 526(41.0) | 169(22.7) | 299(34.7) | 715(43.5) | ||
| Crude OR (95% CI) | Referent | 2.00(1.71–2.35) | 3.41 (2.92–3.98) | 0.76 | Referent | 1.75(1.40–2.18) | 2.68(2.19–3.26) | 0.28 |
| Adjusted OR (95% CI) | Referent | 1.68(1.38–2.05) | 2.88(2.36–3.52) | 0.23 | Referent | 1.61(1.22–2.11) | 2.26(1.75–2.92) | 0.24 |
| Cardiogenic shock | ||||||||
| Events, n (%) | 113(4.4) | 102(6.6) | 139(7.7) | 58(5.7) | 151(7.6) | 479(7.2) | ||
| Crude OR (95% CI) | Referent | NA | NA | <0.001 | Referent | 1.30(0.90–1.87) | 1.33(0.96–1.84) | 0.60 |
| Adjusted OR (95% CI) | Referent | NA | NA | 0.02 | Referent | 1.28(0.82–1.99) | 1.38(0.91–2.10) | 0.42 |
| In-hospital mortality | ||||||||
| Events, n (%) | 108(4.2) | 171(11.1) | 345(19.1) | 58(6.8) | 151(13.8) | 479(19.5) | ||
| Crude OR (95% CI) | Referent | 2.77(2.15–3.56) | 5.76(4.59–7.23) | 0.15 | Referent | 2.11(1.54–2.90) | 3.49(2.62–4.65) | 0.41 |
| Adjusted OR (95% CI) | Referent | 2.83(2.09–3.84) | 5.21(3.90–6.98) | 0.13 | Referent | 2.10(1.43–3.08) | 3.32(2.32–4.75) | 0.22 |
| 30-hospital mortality | ||||||||
| Events, n (%) | 129(5.1) | 213(13.8) | 427(23.8) | 64(7.5) | 166(15.2) | 590(24.1) | ||
| Crude HR (95% CI) | Referent | 2.94(2.33–3.71) | 5.78(4.68–7.14) | 0.91 | Referent | 1.95(1.44–2.66) | 3.74(2.85–4.92) | 0.80 |
| Adjusted HR (95% CI) | Referent | 2.90(2.19–3.85) | 5.10(3.90–6.66) | 0.80 | Referent | 1.91(1.33–2.76) | 3.44(2.46–4.80) | 0.42 |
Model adjusted for race, marital status, study period, medical history, AMI-associated characteristics, and length of stay.
†
p values for interaction terms between age and study period
*
NA: Not applicable. Among men, since age differences in AF and cardiogenic shock have changed significantly over time, adjusted ORs for each study period were calculated separately and are presented in the text; there were no overall ORs for these outcomes.