Figure 6.

Adjusted odds ratios for association of 3 types of sleep difficulty (trouble falling asleep, waking up several times, waking up earlier than planned, all occurring 3 or more nights per week during the past 2 weeks) with estradiol (E2) levels (increased sleep difficulty associated with lower levels) and follicle stimulating hormone (FSH) levels (increased sleep difficulty associated with higher levels). All 3 sleep models adjusted for site, age, race/ethnicity, current hormone therapy use, blood draw in cycle day 2–5 window, depressive symptoms, anxiety symptoms, sleep medication, smoking, life events, nocturia, physical symptoms, and bodily pain. Models for Wake Several Times also adjusted for number of med conditions. Adapted using data from Kravitz et al (2008).³²