Table 2.
Genotype and allele frequencies of ICOS polymorphisms and their associations with breast cancer risk
| SNP | Study cohort | Validation cohort | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype and allele |
Cases n = 609(%) |
Controls n = 665(%) |
OR (95% CI)5 | P value | Cases n = 619(%) |
Controls n = 682(%) |
OR (95% CI)5 | P value | |
| rs118890311 | CC | 248(40.92) | 281(43.03) | reference | |||||
| CT | 286(47.19) | 293(44.87) | 1.104(0.872,1.398) | 0.411 | |||||
| TT | 72(11.88) | 79(12.10) | 1.025(0.713,1.472) | 0.896 | |||||
| C | 782(64.52) | 855(65.47) | reference | ||||||
| T | 430(35.48) | 451(34.53) | 1.039(0.882,1.224) | 0.647 | |||||
| rs10932029 | TT | 523(85.88) | 599(90.08) | reference | 522(84.33) | 614(90.03) | reference | ||
| CT | 82(13.46) | 64(9.62) | 1.475(1.042,2.088) | 0.029 | 95(15.35) | 66(9.68) | 1.693(1.201,2.350) | 0.002 | |
| CC | 4(0.66) | 2(0.30) | 2.348(0.427,12.904) | 0.326 | 2(0.32) | 2(0.29) | 1.171(0.164,8.353) | 0.875 | |
| T | 1128(92.61) | 1262(94.89) | reference | 1139(92.00) | 1294(94.87) | reference | |||
| C | 90(7.39) | 68(5.11) | 1.490(1.076,2.063) | 0.016 | 99(8.00) | 66(5.13) | 1.595(1.162,2.189) | 0.004 | |
| rs46753742 | CC | 136(22.48) | 165(25.82) | reference | |||||
| CT | 320(52.89) | 325(50.86) | 1.193(0.907,1.571) | 0.207 | |||||
| TT | 149(24.63) | 149(23.32) | 1.216(0.882,1.677) | 0.233 | |||||
| C | 592(48.93) | 655(51.25) | reference | ||||||
| T | 618(51.07) | 623(48.75) | 1.099(0.939,1.286) | 0.241 | |||||
| rs101830873 | AA | 438 (72.16) | 487(74.01) | reference | |||||
| AC | 154(25.37) | 155(23.57) | 0.909(0.702,1.177) | 0.469 | |||||
| CC | 15(2.47) | 16(2.43) | 0.951(0.454,1.993) | 0.894 | |||||
| A | 1030(84.84) | 1129(85.79) | reference | ||||||
| C | 184(15.16) | 187(14.21) | 0.998(0.826,1.158) | 0.795 | |||||
| rs109320374 | CC | 568(93.42) | 618(94.93) | reference | |||||
| CT | 40(6.58) | 33(5.07) | 1.326(0.824,2.133) | 0.245 | |||||
| TT | 0 | 0 | -- | -- | |||||
| C | 1176(96.71) | 1269(97.47) | reference | ||||||
| T | 40(3.29) | 33(2.53) | 1.315(0.823,2.100) | 0.252 | |||||
1 cases n = 606, missing n = 3; controls n = 653, missing n = 12.
2 cases n = 605, missing n = 4; controls n = 639, missing n = 26.
3 cases n = 607, missing n = 2; controls n = 658, missing n = 7.
4cases n = 608, missing n = 1; controls n = 651, missing n = 14.
5ORs were adjusted for age
Abbreviations: OR = odds ratio; CI = confidence interval