Table 1.

Kinetic parameters of the VEGF system.

	Value	Reference
Diffusivity (cm2/s)
VEGF	6.88 × 10−7	Vempati et al. (2010)
sFlt	5.07 × 10−7	See text
VEGF–sFlt	4.52 × 10−7	See text
sFlt–VEGF–sFlt	4.14 × 10−7	See text
VEGF binding to mFlt
kon (nM−1 s−1)	2.2 × 10−2	Mac Gabhann and Popel (2007a)
koff (s−1)	2.6 × 10−2	Mac Gabhann and Popel (2007a)
VEGF binding to Flk-1
kon (nM−1 s−1)	4.4 × 10−3	Mac Gabhann and Popel (2007a)
koff (s−1)	2.6 × 10−2	Mac Gabhann and Popel (2007a)
VEGF binding to sFlt-1
kon (nM−1 s−1)	5.5 × 10−1	See text
koff (s−1)	2.6 × 10−2	See text
VEGF binding to ECM
kon (nM−1 s−1)	4.2 × 10−4	Wu et al. (2010b)
koff (s−1)	1.0 × 10−2	Wu et al. (2010b)
sFlt-1 binding to ECM
kon (nM−1 s−1)	4.2 × 10−4	Wu et al. (2010b)
koff (s−1)	1.0 × 10−2	Wu et al. (2010b)
sFlt-1 binding to mFlt
kon (nM−1 s−1)	2.2 × 10−2	See text
koff (s−1)	1.0 × 10−2	See text
sFlt-1 binding to Flk-1
kon (nM−1 s−1)	2.2 × 10−2	See text
koff (s−1)	1.0 × 10−2	See text
Coupling rate of bound membrane receptors (cm2 nmol−1 s−1)	2.1 × 105	Mac Gabhann and Popel (2007a)
Coupling rate of empty receptors (cm2 nmol−1 s−1)	105	Mac Gabhann and Popel (2007a)
Rate of receptor binding second receptor in ternary complex (s−1)	0.446	Mac Gabhann and Popel (2007a)
Rate of VEGF binding second receptor in ternary complex (s−1)	0.949	Mac Gabhann and Popel (2007a)
Dissociation rate of empty receptors (s−1)	10−2	Mac Gabhann and Popel (2007a)
Degradation of volumetric species (s−1)	10−4	Derived from Storkebaum et al. (2005)
Surface receptor internalization and insertion rate (s−1)	2.8 × 10−4	Wu et al. (2010b)
VEGF secretion rate (nmol cm−2 s−1; Figure 2)	5.0 × 10−10	See text
VEGF secretion rate (nmol cm−2 s−1; Figures 3–5)	2.8 × 10−11	See text
sFlt secretion rate (nmol cm−2 s−1)	1.86 × 10−9	See text
Tip cell sFlt-1 secretion rate (nmol cm−2 s−1; Figure 5)	1.86 × 10−10	See text