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LGR4 and LGR5 are new regulators of Wnt and R-spondin signalling. (A–F) Wnt luciferase reporter assays in HEK293T cells stimulated with the indicated constructs or Wnt3a and/or Rspo3-ΔC, or Rspo3-ΔC+ΔTSP, or Rspo3-ΔC+ΔFurin-conditioned medium, in the presence of the indicated small interfering RNAs. Co, control medium. RLA, relative luciferase activity. TSP, thrombospondin. Error bars indicate s.d. values, n=3; * indicates P<0.001 by Student's t-test.
