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. 2011 Jul 1;39(18):8237–8247. doi: 10.1093/nar/gkr381

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — A crystal structure of RT in complex with a dsDNA substrate (PDB 3KK2); only a portion of the dsDNA substrate that extends 12 bp from the RNase H active site is shown to approximate the position of the stem of RT1t49(−5), the positions equivalent to the 5′- and 3′-ends of the stem are indicated. The figure illustrates how the stem of RT1t49(−5) can protect K353. Residues N255 and N265 that play a role in recognition of RT1t49 are shown (cyan). N255 is not contacted by the nucleotides in the 12 bp shown, and N265 is in proximity to the 5′-end of the portion of the template stand that is shown.