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. 2011 Jul 1;39(18):8017–8028. doi: 10.1093/nar/gkr401

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Effect of muAPE1 on gene regulation. (A) definition of distance (D) to assess the extent of ‘enhancement’ by muAPE1 (or wtAPE1). Genes were grouped based on their fold increase/decrease by dox for 16 h. In the example, D-value was calculated for a gene that was activated by muAPE1 at highest, then by wtAPE1, and by ctl at least. I_dox₊ and I_dox_-: gene expression dosages with or without doxycycline. (B) Histograms of D values. Left: genes that are activated; Right: genes that are suppressed by wtAPE1 and ub-APE1. (C) Median values of the histograms in (B).