Table 3.

Mutation rates (µ_ave) predicted for equimolar or optimized nucleotide ratios, based on either experimental rates or thermodynamic lower bounds

		Equimolar ratios		Optimized ratios
	Rates from:	Experiment	Theory	Experiment	Theory
Template	Primer
RNA	RNA	22 ± 1%	3%	8.4 ± 0.9%	0.5%
DNA	DNA	11 ± 4%	0.6%	5.8 ± 0.8%	0.2%
RNA	DNA	21.5 ± 0.4%	2%	9.4 ± .05%	0.4%
DNA	RNA	28 ± 4%	2%	21 ± 3%	0.6%

Error bars given are standard deviations from calculations based on duplicate batches of experimental mutation rates.