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. 2009 Oct 30;1(3):630–646. doi: 10.3390/v1030630

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 1. — Insertional activation of myc genes in WHV-induced woodchuck HCCs. The c-myc, N-myc1 and N-myc2 loci are represented as a line with exons as boxes and WHV insertion sites are shown with arrows. Under each locus are shown the preferred integration sites of retroviruses including murine leukemia virus (MLV), feline leukemia virus (FeLV), avian leukemia virus (ALV) and avian reticuloendotheliosis virus (REV). The b3n and win loci are located at 10 and 180 kb downstream of N-myc2 on the woodchuck X chromosome. Percentages of WHV integration at each locus in a panel of 70 woodchuck tumors analyzed are shown on the right side.