Table 2.
Host proteins that interact with HDV RNA.
| Host protein | Proposed Function | References |
|---|---|---|
| Adenosine deaminase acting on RNA (ADAR 1) | Post-transcriptional modification of the antigenome that results in production of HDAg-L | [15] |
| Glyceraldehydes 3-phosphate dehydrogenase (GAPDH) | Enhances delta ribozyme activity | [58,59] |
| Double-stranded RNA-activated protein kinase R (PKR) | Recruitment to HDAg for post-translational modification Repression of antiviral response | [60,61] |
| RNAP I | Antigenome synthesis | [62] |
| RNAP II | Genome synthesis, mRNA synthesis, Antigenome synthesis | [63–66] |
| RNAP III | Unknown | [62] |
| Polypyrimidine tract-binding protein associated splicing factor (PSF) | Suspected involvement in recruitment of HDV RNA to RNAP II | [67] |
| 54 kDa nuclear RNA-binding protein (p54nrb) | Unknown | [59] |
| Heterogeneous nuclear ribonucleoprotein L (hnRNPL) | Unknown | [59] |
| Arginine/serine-rich splicing factor (ASF) | Unknown | [59] |
| Eukaryotic elongation factor 1A1 (eEF1A1) | Unknown | [59] |