Table 2.
Comparison of areas under curve with oral HDP-[2-14C]-CDV and intraperitoneal [2-14C]-CDV in mouse tissues.
| AUC0-72hr | AUC Ratio | ||
|---|---|---|---|
| Tissue | CDV | HDP-CDV | H/C |
| Brain | 0.87 | 3.96 | 4.6 |
| Heart | 3.46 | 14.26 | 4.1 |
| Liver | 39.6 | 1366.0 | 34.5 |
| Lung | 6.27 | 49.9 | 8.0 |
| Kidney | 1093.0 | 203 | 0.19 |
| Spleen | 9.92 | 53.2 | 5.4 |
Data are nmol/gm.hrs after a single oral dose of 10 mg/kg HDP-[2-14C]-CDV or a molar equivalent intraperitoneal dose of [2-14C]-CDV (5.6 mg/kg). Ratio column abbreviation: H = HDP-CDV, C = CDV. Adapted from Reference [31].