Table 2.
Comparison of neuraminidase inhibition IC50 data generated by JASPR and Robosage software.
| Subtype | Isolates analyzed (n) |
Mean IC50a (±SD)b, nM |
|||||
|---|---|---|---|---|---|---|---|
|
Oseltamivir |
Zanamivir |
||||||
| JASPR | Robosage | rc | JASPR | Robosage | r | ||
| Seasonal A/H1N1 (H275 wildtype)d | 8 | 0.22±0.05 | 0.26±0.07 | 0.970 | 0.47±0.34 | 0.56±0.47 | 0.999 |
| Seasonal A/H1N1 (H275Y variants)e | 106 | 113.38±45.63 | 128.57±55.93 | 0.986 | 0.50±0.23 | 0.58±0.30 | 0.990 |
| Pandemic H1N1 | 100 | 0.21±0.06 | 0.25±0.06 | 0.939 | 0.28±0.10 | 0.31±0.13 | 0.988 |
| A/H3N2 | 125 | 0.24±0.13 | 0.27±0.16 | 0.994 | 1.30±0.93 | 1.48±1.08 | 0.994 |
| B | 106 | 3.56±0.94 | 3.84±1.05 | 0.990 | 3.93±1.32 | 4.19±1.45 | 0.995 |
a
Determined in the chemiluminescent neuraminidase inhibition assay.
b
SD, standard deviation of IC50 values.
c
r, Pearson correlation coefficient.
d
H275 wildtype, oseltamivir-sensitive isolates.
e
H275Y variants, oseltamivir-resistant virus isolates.