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Epo-independent erythroid proliferation and differentiation induced by SFFV. Normal erythroid cells require Epo for proliferation and differentiation into red blood cells (RBC). However, erythroid cells infected with SFFV-P or SFFV-A in vitro can proliferate in the absence of Epo, as shown by the development of Epo-independent erythroid colonies. Those infected with SFFV-P, but not SFFV-A, are red, indicating that differentiation also proceeds in the absence of Epo.
