Table 1.
Poxvirus encoded modulators of the ubiquitin-proteasome system. Poxviruses are known to encode a number of modulators of the ubiquitin-proteasome system. Included in this table are ubiquitin homologs encoded by poxviruses, as well as MARCH and p28 E3 ubiquitin ligases, BTB/kelch and Ank/PRANC proteins that associate with cellular ubiquitin ligases, and poxvirus APC/cyclosome regulators.
| Involvement in Ubiquitination | Genus | Virusa | Gene/Protein | Length, aa | VBRC accessionb |
|---|---|---|---|---|---|
| poxvirus-encoded ubiquitin homologs | Avipoxvirus | CNPV-VR111 | 96 | 85 | VP0043569 |
| Betaentomopoxvirus | AMEV-Moyer | 180 | 81 | VP0037620 | |
| Unclassified Poxviridae | MSEV-Tuc | 144 | 80 | VP0038302 | |
| MARCH Poxviral E3 Ubiquitin Ligase | Capripoxvirus | GTPV-Pellor | 8 | 162 | VP0044818 |
| LSDV-Nee | 10 | 162 | VP0040213 | ||
| SPPV-A | 8 | 162 | VP0044517 | ||
| Leporipoxvirus | MYXV-Lau | M153 | 206 | VP0038581 | |
| RFV-Kas | gp153R | 201 | VP0038747 | ||
| Suipoxvirus | SWPV-Neb | 9 | 155 | VP0040564 | |
| Yatapoxvirus | TANV-COD | 5 | 156 | VP0067544 | |
| YLDV-Davis | 5 | 156 | VP0040054 | ||
| YMTV-Amano | 4 | 156 | VP0043053 | ||
| p28 Poxviral E3 Ubiquitin Ligase | Avipoxvirus | CNPV-VR111 | 205 197 |
318 275 |
VP0043678 VP0043670 |
| FWPV-Iowa | 157 150 |
311 276 |
VP0037889 VP0037882 |
||
| Capripoxvirus | LSDV-Nee | 140 | 240 | VP0040345 | |
| SPPV-A | 136 | 240 | VP0044645 | ||
| GTPV-Pellor | 127 | 240 | VP0044947 | ||
| Leporipoxvirus | MYXV-Lau | M143 | 234 | VP0038572 | |
| RFV-Kas | gp143R (N1R) | 234 | VP0038740 | ||
| Orthopoxvirus | CMLV-CMS | 14R | 242 | VP0041112 | |
| CPXV-GRI | C7R | 242 | VP0042678 | ||
| ECTV-Mos | 12 | 241 | VP0040932 | ||
| MPXV-ZAR | D5R | 242 | VP0040369 | ||
| VACV IHD-W | p28 | 243 | c | ||
| VARV-BGD75maj | D6Rd | 242 | VP0038767 | ||
| RPXV-Utr | 8 | 242 | VP0041370 | ||
| Suipoxvirus | SWPV-Neb | 138 | 246 | VP0040694 | |
| Yatapoxvirus | TANV-COD | 143R | 234 | VP0067759 | |
| YMTV-Amano | 143R | 236 | VP0043181 | ||
| Unclassified Poxviridae | DPV-W1170_84 | 154 | 245 | VP0045437 | |
| BTB/KELCH proteins associated with cullin-3-based E3 ubiquitin ligase | Capripoxvirus | GTPV-Pellor | 16 141 148 |
562 547 552 |
VP0044826 VP0044951 VP0044958 |
| LSDV-NEE | 19 144 151 |
569 547 550 |
VP0040222 VP0040349 VP0040356 |
||
| SPPV-A | 16 140 147 |
569 547 552 |
VP0044525 VP0044649 VP0044656 |
||
| Leporipoxvirus | MYXV-Lau | M014L M140R |
517 553 |
VP0038442 VP0038569 |
|
| RFV-Kas | gp013L gp0140R |
516 553 |
VP0038613 VP0038737 |
||
| Orthopoxvirus | CMLV-CMS | 21L 24L 38L 172R 186R |
200 512 480 564 501 |
VP0041119 VP0041122 VP0041137 VP0041317 VP0041335 |
|
| CPXV-GRI | D11L C18L G3L A54R B9R B19R |
521 512 485 564 501 557 |
VP0042668 VP0042689 VP0042703 VP0042838 VP0042849 VP0042686 |
||
| ECTV-Mos | 18 27 150 165 |
512 482 563 594 |
VP0040938 VP0040947 VP0041074 VP0041089 |
||
| MPXV-ZAI | D12L D19L C9L |
206 107 487 |
VP0040376 VP0040382 VP0040396 |
||
| TATV-DAH68 | 24 43 181 196 |
150 480 219 209 |
VP0052942 VP0052961 VP0053099 VP0053114 |
||
| VACV-COP | C2L C5L F3L A55R |
512 615 480 564 |
VP0039555 VP0039551 VP0039572 VP0039751 |
||
| RPXV-Utr | 15 18 31 162 |
204 512 480 564 |
VP0041377 VP0041380 VP0041393 VP0041526 |
||
| Suipoxvirus | SWPV-Neb | 6 15 136 |
530 534 574 |
VP0040561 VP0040570 VP0040692 |
|
| Yatapoxvirus | YLDV-Davis | 19L 140R |
522 570 |
VP0040068 VP0040192 |
|
| YMTV-Amano | 19L | 524 | VP0043062 | ||
| Unclassified Poxviridae | DPV-W1170_84 | 25 159 |
529 546 |
VP0045308 VP0045442 |
|
| ankyrin/PRANC proteins associated with cullin-1-based E3 ubiquitin ligase | Avipoxvirus | FWPV-Iowa | 12 14 18 22 26 31 162 218 219 222 227 228 231 232 233 234 240 243 244 246 |
331 437 700 578 436 341 603 461 434 747 361 525 256 482 512 428 410 262 668 592 |
VP0037744 VP0037746 VP0037750 VP0037754 VP0037758 VP0037763 VP0037894 VP0037952 VP0037953 VP0037956 VP0037961 VP0037962 VP0037965 VP0037966 VP0037967 VP0037968 VP0037974 VP0037977 VP0037978 VP0037980 |
| Capripoxvirus | GTPV-Pellor | 142 144 145 149 |
634 498 447 453 |
VP0044952 VP0044954 VP0044955 VP0044959 |
|
| LSDV-Nee | 145 147 148 152 |
634 498 447 489 |
VP0040350 VP0040352 VP0040353 VP0042090 |
||
| SPPV-A | 141 143 144 148 |
631 498 447 484 |
VP0044650 VP0044652 VP0044653 VP0044657 |
||
| Leporipoxvirus | MYXV-Lau | 148R 149R 150R 005R (MT-5) |
675 490 494 483 |
VP0038576 VP0038577 VP0038578 VP0038588 |
|
| Orthopoxvirus | CMLV-CMS | 3L 4L 177L 197R |
585 672 564 783 |
VP0041099 VP0041101 VP0041325 VP0041349 |
|
| CPXV-GRI | D3L D4L D8L (CP77) C1L C11L B3R B16R B18R K1R I2R I3R |
586 672 661 437 614 558 574 795 581 672 586 |
VP0042660 VP0042661 VP0042665 VP0042672 VP0042682 VP0042843 VP0042856 VP0042858 VP0042863 VP0042868 VP0042869 |
||
| ECTV-Mos | 2 5 154 165 |
587 650 564 594 |
VP0040921 VP0040924 VP0041078 VP0041089 |
||
| MPXV-ZAR | B5R J1R N4R B17R |
561 587 437 793 |
VP0040530 VP0040553 VP0040552 VP0040542 |
||
| TATV-DAH68 | 220 187 18 6 |
640 558 661 627 |
VP0053138 VP0053105 VP0052936 VP0052924 |
||
| VACV-Cop | B18R C19L B4R |
574 259 558 |
VP0039778 VP0039532 VP0039761 |
||
| RPXV-Utr | 180 178 166 |
791 574 558 |
VP0041544 VP0041542 VP0041530 |
||
| VARV-BDG75maj | B5R G1R B16R B18R |
558 585 574 787 |
VP0038933 VP0039159 VP0038944 VP0038946 |
||
| Parapoxvirus | ORFV-NZ2 | 8 123 126 128 129 |
516 525 497 500 520 |
VP0047660 VP0047777 VP0047780 VP0047782 VP0047783 |
|
| Suipoxvirus | SWPV-Neb | 141 142 143 144 |
635 485 430 493 |
VP0040697 VP0040698 VP0040699 VP0040700 |
|
| Yatapoxvirus | YLDV-Davis | 148R 147R 146R 11L |
476 491 473 637 |
VP0040200 VP0040199 VP0040198 VP0040060 |
|
| YMTV-Amano | 11L 146R 147R 148R |
637 356 497 483 |
VP0043056 VP0043184 VP0043185 VP0043186 |
||
| Unclassified Poxviridae | DPV-W1170_84 | 164 163 162 160 19 |
493 483 501 641 643 |
VP0045447 VP0045446 VP0045445 VP0045443 VP0045302 |
|
| poxvirus APC/cyclosome regulators | Molluscipoxvirus | MOCV-st1 | 026L | 83 | VP0038021 |
| Parapoxvirus | BSPV-AR02 | 13 | 93 | VP0043354 | |
| ORFV-NZ2 | 14 | 93 | VP0047667 | ||
| Unclassified Poxvirdae | CRV-ZWE | 47 | 81 | VP0066074 | |
| SPV | A11L | 86 | DQ377804e |
Representative strains were chosen for each individual virus, and the viruses are abbreviated: Canarypox virus (CNPV), Fowlpox virus (FWPV), Goatpox virus (GTPV), Lumpy skin disease virus (LSDV), Sheepox virus (SPPV), Myxoma virus (MYXV), Rabbit fibroma virus (RFV), Molluscum contagiosum virus (MOCV), Camelpox virus (CMLV), Cowpox virus (CPXV), Ectromelia virus (ECTV), Monkeypox virus (MPXV), Taterapox virus (TATV), Vaccinia virus (VACV), Variola virus (VARV), Bovine papular stomatitis virus (BPSV), Orf virus (ORFV), Swinepox virus (SWPV), Tanapox virus (TANV), Yaba-like disease virus (YLDV), Yaba monkey tumor virus (YMTV), Amsacta moorei enomopoxvirus (AMEV), Melanoplus sanguinipes entomopoxvirus (MSEV), Mule deer poxvirus (DPV), Nile crocodile poxvirus (CRV), Squirrel poxvirus (SPV).
VBRC accession numbers were obtained from the Poxvirus Bioinformatics Resource Center [28].
The complete VACV-IHD-W genome has not been published and an accession number is not available.
D6R is also known as D4R, B5R or B6R, depending on the strain of VARV.
The SPV genome is not available in the Poxvirus Bioinformatics Resource Center so the accession number from GENBANK was used.