Table 1.

Binding affinity [29,35] and antiviral potency [36] of FDA approved HIV-1 protease inhibitors.

	Ki (nM)
Inhibitor	WT/Q7K	L10I, G48V, I54V, L63P, V82A	D30N, L63P, N88D	L10I, L63P, A71V, G73S, I84V, L90M	Antiviral EC50 (nM)
Saquinavir	0.065	90	1.0	78	26
Indinavir	0.18	34	0.73	21	40
Ritonavir	0.055	3.0	0.46	2.8	65
Nelfinavir	0.28	15	3.5	19	71
Amprenavir	0.10	0.15	0.21	1.40	44
Lopinavir	0.005	6.1	0.04	0.90	10
Atazanavir	0.046	0.33	0.009	0.49	15
Tipranavir	0.088	0.014	0.001	0.032	500
Darunavir	0.008	0.005	0.041	0.025	1