Table 2.
The major non-active site mutation positions which cause decreased susceptibility to one or more PIs [22]. The known polymorphisms are listed for subtype B [40].
| Positions | Wild-type Amino Acid | Most Frequent Mutations | Polymorphic/Non-polymorphic |
|---|---|---|---|
| 10 | L | FI | (L10I) Polymorphic |
| (L10F) Non-polymorphic | |||
| 11 | V | L | Non-polymorphic |
| 20 | K | T | Non-polymorphic |
| 33 | L | F | Non-polymorphic |
| 35 | E | GN | Non-polymorphic |
| 43 | K | T | Non-polymorphic |
| 46 | M | IL | Non-polymorphic |
| 54 | I | ALMSTV | Non-polymorphic |
| 58 | Q | E | Non-polymorphic |
| 73 | G | CST | Non-polymorphic |
| 74 | T | PS | Non-polymorphic |
| 76 | L | V | Non-polymorphic |
| 88 | N | DS | Non-polymorphic |
| 89 | L | V | Non-polymorphic |
| 90 | L | M | Non-polymorphic |