Table 3.

Protease positions that differ between HIV-1 clades. The line highlighted in orange shows amino acid substitutions that are associated with inhibitor resistance in clade B.

Position	10	12	13	14	15	20	35	36	41	57	61	69	82	89	93
Clade B	L	T	I	K	I	K	E	M	R	R	Q	H	V	L	I
Resistance Associated Mutations in clade B	I		V			I/R	D	I					A	M	L
Clade A1/A2	I		V	R			D	I	K	K		K		M
Clade C		S			V			I/V	K/N			K		M	L
Clade D	V		V					I	K
Clade F1/F2	V/I	S			V	R	D	I/V	K	K	N			M
Clade G	I		V	R		I	D	I	K			K	I	M
Clade H			V			R		I	K					I
Clade J			V	R		R		I	K		E			M
Clade K	I				V	R		I	K					M
CRF01_AE			V			R	D	I	K			K		M
CRF02_AG	V/I		V	R		I		I	K			K		M