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. 2010 Mar 30;2(4):900–926. doi: 10.3390/v2040900

Figure 2.

Figure 2.

A Crystal structure of HIV-1 RT (PDB code: 1RTD. The p51 subunit is shown in orange, while the p66 subunit is divided into the fingers (cyan), connection (blue) and RNase H (grey) subdomains. The residues of the conserved DEDD motif are shown and red and marked with arrows. B Crystal structures of the RNase H domain of HIV-1 RT (PDB code:1RTD) [5], human RNase H1 (PDB code: 2QKB) [12] and E. coli RNase H1 (PBD code: 1WSJ). All three show the same mixed beta-sheet with asymmetric alpha helices, while the human and E. coli RNases H contain the C-helix, or basic loop.