Figure 4.

Four different views showing the local environment around the HIV-1 RT polymerase active site and the putative INDOPY-1 binding site. The structure of the trapped RT/primer-template/incoming dNTP catalytic complex [17] is represented. The three catalytic aspartic acids are shown as red sticks, the two required magnesium ions as yellow spheres, the DNA template in light yellow (positions n, n + 1 and n + 2 are labeled) and the DNA primer in orange. Residues affecting the inhibitory effect of INDOPY-1 (F61, K65, Y115 and M184) and the incoming dTTP are also shown as sticks. The solvent accessible surface of the dTTP is shown in orange transparency. Adapted from [25].