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. 2011 Apr 12;3(4):336–346. doi: 10.3390/v3040336

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 2. — Model of herpesvirus entry, maturation and egress. (A) Herpes virion “surfing” towards the plasma membrane along membrane protrusions for entry. (B) Capsid trafficking toward the nuclear periphery for budding via a myosin motor on F-actin. (C) U_S3-mediated depolymerization of actin stess fibers. (D) U_S3-mediated generation of membrane projection and cell-to-cell spread of herpesvirus. (E) Myosin IIA- and Rab6-dependent fission of nascent vesicles from the Golgi body. (F) Enveloped virion within a TGN-derived vesicle trafficking through cortical actin via myosin Va toward the plasma membrane for secretion.