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Structural and Functional domains of the HCV core protein. Core is made as a 191 residue long polypeptide, and is trimmed by a signal peptide peptidase, down to a 177-residue mature protein [46,57]. Various synthetic C-terminally truncated versions of recombinant core have been used in order to characterize its functional domains: core82 [59], core106 [23], core122, “D1” [55], core169 [55], and core177, “D2” [39,57].
