. 2010 Sep 16;2(9):1968–1983. doi: 10.3390/v2091968

Table 3.

Effect of oral treatment with 4′-thioIDU on mortality of BALB/c mice inoculated intranasally with Cowpox Virus ^a.

Treatment^b	Mortality		P-value	MDD + SD^c	P-value
Treatment^b	Number	Percent	P-value	MDD + SD^c	P-value
Vehicle + 3 days	14/15	93		11.9 ± 2.2
CDV + 3 days
15 mg/kg	0/14	0	<0.001
4′-thioIDU + 3 days
15 mg/kg	1/15	7	<0.001	14.0	NS^c
5 mg/kg	0/15	0	<0.001
1.5 mg/kg	2/15	13	<0.001	14.0 ± 5.7	NS^c
Vehicle + 4 days	15/15	100		11.7 ± 2.3	NS
CDV + 4 days
15 mg/kg	0/15	0	<0.001
4′-thioIDU + 4 days
5 mg/kg	4/15	27	<0.001	13.3 ± 1.3	<0.05
Vehicle + 5 days	12/15	80		14.6 ± 3.9
CDV + 5 days
15 mg/kg	4/15	27	0.01	10.5 ± 1.9	0.07
4′-thioIDU + 5 days
5 mg/kg	13/15	87	NS^c	9.8 ± 1.3	<0.001

^a.

Adapted from [25];

^b.

4′-thioIDU was suspended in vehicle (10% DMSO in 0.4% CMC) and given orally in 0.2 ml doses. CDV was prepared in sterile saline and given i.p. in 0.1 ml doses. Animals were treated twice daily with vehicle or 4′-thioIDU for five days, except for CDV which was dosed once daily, beginning 3, 4 or 5 days post viral inoculation;

^c.

MDD = mean day of death; SD = standard deviation; NS = not significant when compared to the placebo control.