Table 4.
Activity of 4′-thioIDU Against Resistant Mutants of Vaccinia Virusa.
| Compound | WR (EC50, μM)b | CDVR 15 (EC50, μM) | VV911 (ST-246R) (EC50, μM) | VVTK::luc TK deficient (EC50, μM) |
|---|---|---|---|---|
| 4′-thioIDU | 0.04 ± 0.02 | 0.04 ± 0.01 | 0.02 ± 0.003 | 0.3 ± 0.01 |
| CDV | 11 ± 1.5 | 62 ± 34 | 33 ± 5.0 | 9.4 ± 0.1 |
| ST-246 | 0.07 ± 0.01 | NDc | >20 ± 0 | NDb |
| IDU | 2.8 ± 0.3 | 1.0 ± 0.1 | 2.4 ± 0.4 | 7.1 ± 4.3 |
a.
Adapted from [25];
b.
Concentration required to reduce plaque formation by 50%. Values presented are the average of duplicate determinations with the standard deviations shown;
c.
Not determined.