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. 2011 Jun 17;3(6):861–885. doi: 10.3390/v3060861

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 4. — Functions of p13. In mitochondria, p13 mediates (1) K⁺ influx, inner mitochondrial membrane potential, and electron transport chain activity to affect (2) Ca²⁺ signaling and (3) ROS production. (4) In the presence of Tax, p13 is ubiquitinated and translocates to the nucleus. In the nucleus, p13 inhibits Tax-CBP/p300 complex formation to decrease transcription of cellular and viral genes.