Figure 2.

C7a significantly increases the survival of RV-ATL tumor bearing mice. Adult female NSG mice were intraperitoneally (IP) injected with 10⁷ fresh, in vivo expanded RV-ATL cells on Day 0. Mice were treated with either C7a (20 μM diluted in PBS) (red line and purple line) or PBS alone (blue line and green line) by IP injection every other day starting on Day 4. Starting on day 22, half the mice from each group were treated with 80 μM C7a (green line and purple line). N = 5 per group for four treatment groups. All mice were treated by IP injections through day 40, and survival was monitored daily. p values (Kaplan Meier test) are shown for each group, compared to no treatment group.