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. 2011 Aug 12;3(8):1417–1431. doi: 10.3390/v3081417

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Comparison of Adenovirus-mediated Dynein Recruitment with Physiological Mechanisms. (A) Cytoplasmic dynein is shown binding to adenovirus directly, and dynactin (yellow) and NudE/NudEL (green), indirectly. (B) Physiological cargoes (e.g., lysosomes, as shown) feature a variety of different dynein recruitment mechanisms, several involving dynactin. Both dynactin and NudE/NudEL are required for motility, and may, potentially, contribute either to dynein recruitment or to mechanochemical regulation, or both.