Figure 3.
Long-term effects of lipopolysaccharide (LPS) preconditioning. (A) Cognitive function: latencies at 4 weeks after injury (average of 24 trials over 3 days) in mice receiving either saline or LPS 5 days before traumatic brain injury (TBI). Data are reported as mean+s.d. (sham: n=4; brain injured: n=12). Analysis of variance (ANOVA): P<0.05 followed by Newman–Keuls post hoc test. #P<0.05 compared with sham. (B) Histopathology: quantification of contusion volume at 5 weeks after injury in mice receiving either saline or LPS 5 days before TBI. Data are reported as mean+s.d. (n=6). ***P<0.001 compared with saline.