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Argonaute 2 localizes into perinuclear weblike structures in Huh7 cells with subgenomic HCV replicon. (A) In Huh7 cells with subgenomic HCV replicon, Ago2 accumulates into a weblike perinuclear pattern, which is devoid of GW182 and Dcp1a proteins. Nuclei are visualized with DAPI. (B,C) Perinuclear structures enriched in nonstructural viral NS5A and NS3 proteins are devoid of GW182. Scale bar corresponds to 20 μm.
