Table 4. Combined effect of dietary folate intake and alcohol consumption on breast cancer risk.
| Ethanol intake (g per day) | Folate intake (μg per day) | No. Cases/ controls | OR (95% CI) a | P-valueb |
|---|---|---|---|---|
| Abstainers | Low | 245/177 | 1.00b | |
| Middle | 229/166 | 0.70 (0.51–0.95) | ||
| High | 186/186 | 0.30 (0.20–0.44) | ||
| >0–<15 | Low | 70/136 | 0.43 (0.30–0.61) | <0.001 |
| Middle | 99/154 | 0.35 (0.25–0.50) | ||
| High | 87/122 | 0.23 (0.15–0.36) | ||
| ⩾15 | Low | 21/18 | 0.93 (0.47–1.84) | |
| Middle | 21/12 | 0.99 (0.46–2.16) | ||
| High | 36/28 | 0.38 (0.20–0.72) |
Abbreviations: CI=confidence interval; OR=odds ratio.
a
Estimates from unconditional logistic regression models included terms for age at interview (continuous), education (none, primary, secondary, tertiary), BMI (5-years ago), oral contraceptive use (never, ever), hormone replacement therapy (never, ever), breast cancer in first-degree relatives (no, yes), total energy intake (continuous), folate intake (continuous), tea drinking (no, yes) and menopausal status (no, yes; only for all women).
b
Reference category.