Table 5. Association between alcohol intake (g per day) and breast cancer risk by hormone receptor status.
|
ER+
|
ER−
|
PR+
|
PR−
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| No. controls | No. cases | OR (95% CI) a | No. cases | OR (95% CI) a | No. cases | OR (95% CI) a | No. cases | OR (95% CI) a | |
| All women | |||||||||
| None | 529 | 277 | 1.00b | 215 | 1.00b | 257 | 1.00b | 234 | 1.00b |
| >0–<15 | 412 | 118 | 0.62 (0.48–0.81) | 74 | 0.52 (0.38–0.70) | 107 | 0.58 (0.44–0.76) | 84 | 0.56 (0.42–0.75) |
| ⩾15 | 58 | 29 | 1.13 (0.69–1.86) | 32 | 1.56 (0.95–2.53) | 28 | 1.11 (0.67–1.84) | 34 | 1.60 (0.99–2.59) |
| Premenopausal women | |||||||||
| None | 332 | 184 | 1.00b | 128 | 1.00b | 178 | 1.00b | 133 | 1.00b |
| >0–<15 | 297 | 89 | 0.64 (0.47–0.87) | 54 | 0.57 (0.40–0.83) | 86 | 0.63 (0.46–0.86) | 56 | 0.59 (0.41–0.85) |
| ⩾15 | 38 | 19 | 1.03 (0.56–1.92) | 19 | 1.47 (0.78–2.76) | 22 | 1.21 (0.67–2.18) | 17 | 1.35 (0.70–2.61) |
| Postmenopausal women | |||||||||
| None | 197 | 93 | 1.00b | 87 | 1.00b | 79 | 1.00b | 101 | 1.00b |
| >0–<15 | 115 | 29 | 0.56 (0.34–0.94) | 20 | 0.37 (0.21–0.68) | 21 | 0.46 (0.26–0.81) | 28 | 0.47 (0.28–0.79) |
| ⩾15 | 20 | 10 | 1.49 (0.63–3.51) | 13 | 1.80 (0.80–4.05) | 6 | 1.03(0.37–2.87) | 17 | 2.04 (0.97–4.31) |
Abbreviations: CI=confidence interval; OR=odds ratio.
a
Estimates from unconditional logistic regression models included terms for age at interview (continuous), education (none, primary, secondary, tertiary), BMI (5-years ago), oral contraceptive use (never, ever), hormone replacement therapy (never, ever), breast cancer in first-degree relatives (no, yes), total energy intake (continuous), folate intake (continuous), tea drinking (no, yes) and menopausal status (no, yes; only for all women).
b
Reference category.