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. 2011 Aug 23;105(7):1002–1011. doi: 10.1038/bjc.2011.303

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Copyright © 2011 Cancer Research UK

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Proteolysis of GS-168AT2 by hEC is associated with an important downregulation of CD9P-1 at the cell surface. Human EC were incubated with GS-168AT2, and collected at the indicated time, washed twice with vehicle, lysed and lysates resolved by SDS–PAGE. (A) The kinetic of GS-168AT2 degradation by hEC was monitored by WB of cell lysates with the 229T mAb and compared with GAPDH as an internal standard. Arrows indicate the intact GS-168AT2 and the proteolytic fragments (15 kDa) of GS-168AT2 recognised by the 299T mAb. (B) The downregulation of CD9P-1 was monitored by WB of cell lysates with the 299T mAb and compared with GAPDH as an internal standard. Western blots presented in this figure are representative images of at least three independent experiments.