Table 2. Erlotinib dose escalation.

	Maximum dose level		Final dose level
Dose level	Number of patients	Median days of treatment (range)	Number of patients	Median days of treatment (range)
100	—	—	2 (5%)	81 (21–140)
125	—	—	2 (5%)	84 (14–153)
150	4 (10%)	22 (12–49)	6 (14%)	63 (42–119)
175	—	—	2 (5%)	120 (30–210)
200	13 (31%)	14 (2–18)	15 (36%)	15 (2–342)
225	9 (21.5%)	14 (8–27)	5 (12%)	14 (8–14)
250	7 (17%)	8 (5–50)	4 (10%)	14 (5–50)
275	1 (2%)	26	2 (5%)	322 (26–618)
300	5 (12%)	51 (9–93)	2 (5%)	65 (51–78)
350	1 (2%)	14	1 (2%)	14
425	1 (2%)	1
475	1 (2%)	41	1 (2%)	41