Table 3. Multivariate analysis (Cox regression) of sex, age, karyotype, IPSS and Ang-1 expression on the overall survival in MDS patients.

Variable	Hazard ratio	95% CI	P-value
Sexa	1.137	0.719–1.799	0.582
Ageb	2.02	1.266–3.222	0.003
Karyotypec	2.031	1.221–3.377	0.006
IPSSd	2.808	1.796–4.389	<0.001
Ang-1 e	1.866	1.204–2.892	0.005

Abbreviations: IPSS=international prognosis scoring system; Ang-1=angiopoietin-1; MDS=myelodysplastic syndromes; CI=confidence interval.

^aMale vs female.

^bAge ⩾60 years old vs age <60 years old.

^cPoor karyotype vs good and intermediate karyotypes.

^dIntermediate-2/high risk vs low risk/intermediate-1.

^eHigher Ang-1 expression vs lower Ang-1 expression.