Table 3.
Biomechanically responsive genes involved in mechanosignaling, response to injury, and atherogenesis
| Accession no. (GenBank) | Gene name (UniGene) | Laminar/static | Turbulent/static | Function |
|---|---|---|---|---|
| AA252968 | Annexin VIII | 2.2 | 1.9 | Anticoagulant |
| AA478589 | Apolipoprotein E* | 2.1 | ‡ | Lipid metabolism |
| AA598561 | CD164 antigen, sialomucin | −2.4 | −2.6 | Adhesion receptor |
| AA451684 | CD1D antigen, d polypeptide | −1.9 | 1.5 | Lipid-antigen presentation |
| AA136271 | CD58 antigen, (lymphocyte function-associated antigen 3) | −2.2 | −1.7 | T cell recognition |
| H65052 | Coagulation factor II (prothrombin) | −2.4 | ‡ | Pro-coagulant |
| AA598794 | Connective tissue growth factor† | 4.1 | 5.7 | Pleotropic functions |
| AA448157 | Cytochrome P450, subfamily I (dioxin-inducible), B1* | 2.7 | ‡ | Estradiol hydroxylation |
| W31074 | Fatty-acid-Coenzyme A ligase, long-chain 3 | −2.3 | −1.9 | Fatty acid metabolism |
| AA719257 | Fibrogenic lymphokine† | −1.2 | 1.7 | Fibrosis |
| R62612 | Fibronectin 1 | 2.4 | ‡ | Extracellular matrix |
| R43581 | G protein, alpha stimulating activity polypeptide 1 | 2.6 | 2.0 | GPCR signaling |
| AA487912 | G protein, beta polypeptide 1 | 2.5 | ‡ | GPCR signaling |
| H72187 | G protein, gamma 5 | 4.6 | ‡ | GPCR signaling |
| H68922 | Integrin, alpha 1 | −1.9 | −4.0 | Extracellular matrix receptor |
| AA446251 | Laminin, beta 1 | −1.4 | −3.0 | Extracellular matrix |
| AA630328 | Lectin, galactoside-binding, soluble, 3 (galectin 3) | 1.2 | 2.5 | RAGE, pleiotropic |
| AA630104 | Lipase A, lysosomal acid, cholesterol esterase | −2.1 | −1.0 | Cholesterol metabolism |
| R76808 | Low density lipoprotein-related protein 2 | −1.1 | −2.4 | Lipoprotein transport |
| AA143331 | Matrix metalloproteinase-1† | 1.7 | 1.2 | Extracellular matrix |
| AA155913 | Matrix-gla protein† | 1.8 | 0.9 | Vascular calcification |
| R51346 | Methionine aminopeptidase; elF-2-associated p67 | −2.3 | 1.0 | Angiogenesis |
| R60722 | Purinergic receptor P2X, ligand-gated ion channel, 4* | −2.3 | ‡ | Purinergic receptor |
| R96668 | Small inducible cytokine subfamily A (Cys-Cys), member 15 | −2.3 | ‡ | Chemokine |
| AA436142 | Sparc/osteonectin | 2.8 | ‡ | Extracellular matrix |
| AA453335 | Thioredoxin reductase* | 4.1 | ‡ | Redox |
| AA437064 | Thrombospondin 4 | −1.3 | −2.1 | Extracellular matrix |
| R76436 | Thromboxane A synthase 1 (cytochrome P450, subfamily V) | 1.3 | −1.6 | Vasoconstriction, procoagulant |
*
Verified by Western blot.
†
Verified by TaqMan assay.
‡
Not detected.