Table 1.
Common insertion sites (CIS) or activated proto-oncogenes in MuLV-induced tumors1.
| VIRUS | DISEASE | CIS or PROTO-ONCOGENE |
|---|---|---|
| Moloney MuLV | T-lymphoma | |
| In mice: | ||
| c-myc, pim-1, pvt-1/mis-1/mlvi-1, lck, pim-2a, n-myca, bmi-1a, frat-1a, pal-1/gfi-1a | ||
| In rats: | ||
| c-myc, pvt-1/mis-1/mlvi-1, mlvi-2, mlvi-3, mlvi-4, dsi-1, lck, tpl-1/ets-1a, tpl-2a, gfi-1/pal-1a, gfi-2/IL-9R | ||
| Myeloid leukemia | c-myb, mml-1 | |
| AKR MuLV/Gross Virus; SL3-3 MuLV | T-lymphoma | c-myc, gin-1, n-ras |
| RadLV (Radiation leukemia virus) | T-lymphoma | c-myc, pim-1, vin-1/cyclinD2, notch1, kis-1, kis-2 |
| Friend MuLV | Erythroleukemia | fli-1, fre-2 |
| Myeloid leukemia | fis-1, fim-1, evi-1/fim-3, c-fms/fim-2 | |
| Endogenous MuLV (AKXD, BXH-2 recombinant inbred mice) | Myeloid leukemia | evi-1/fim-3, evi-2, meis-1 and others1 |
| B-lymphoma | evi-3 and others1 | |
| Abelson MuLV (contains v-abl oncogene) | B-lymphoma | ahi-1, ahi-2 (M-MuLV helper inserted) |
| Friend SSFV (SFFV gp52c is an oncogene) | Erythroleukemia | Spi-1, p53b |
1
Data from retroviral tagging of mice genetically predisposed to cancer (e.g., myc transgenic mice) are not included here. They can be found in the Mouse Retrovirus Tagged Cancer Gene (RTCG) database [65,66].
a
Insertions associated with tumor progression or that collaborate with other proto-oncogene activations;
b
Insertion at p53 inactivates its function;
c
gp52 oncogene is a deleted form of endogenous retroviral envelope protein.