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Metabolic interplay between CAFs and cancer cells. Tumor cells are characterized by an high proliferation rate and consequently undergo a strong activation of anabolic pathways that allow rapid growing. In the model reported in this figure cancer cells force CAFs to undergo aerobic glycolysis, and to produce energy-rich nutrients (lactate or pyruvate) which are used in cancer cells for TCA cycle, ATP production, sustaining anabolism and growth.
