Table 2.
Role of Caveolin in radio- and chemoresistance
| Authors | Year | Tumor entity | Main findings | Reference |
|---|---|---|---|---|
| Park et al. | 2010 | kidney | Caveolin-1 knockdown sensitized human renal carcinoma cells to doxorubicin-induced apoptosis and reduced lung metastasis in a mouse model | [27] |
| Hehlgans et al. | 2009 | pancreas | Caveolin-1 knockdown sensitized pancreatic tumor cell lines grown in 3D lrECM to X-rays | [47] |
| Dittmann et al. | 2008 | lung, head & neck (SCC) | EGFR receptor internalization and transport into the nucleus upon irradiation depended on Src activation and Caveolin-1 | [70] |
| Ho et al. | 2008 | lung (NSCLC) | Caveolin-1 expression was associated with a poor prognosis and with drug resistance in advanced NSCLC patients after Gemcitabine-based chemotherapy | [63] |
| Cordes et al. | 2007 | pancreas | Knockdown of Caveolin-1 radiosensitized pancreatic cancer cell lines to ionizing radiation | [69] |
| Li et al. | 2005 | Enhanced radiosensitivity of Caveolin-1 deficient mice was associated with increased apoptosis and abnormal proliferation of intestinal crypt stem cells of the small intestine | [68] |