Table 1.
Pharmacological properties of Statins
| Statin Name | Brand Name | Lipophilicity | Bioavailability % | Hepatic Extraction (%absorbed) | Observed Mechanism in PCa cells in vitro |
|---|---|---|---|---|---|
| Atorvastatin | Lipitor | Lipophilic (+4.1) | 12 | 20-30 | Growth inhibition, induction of apoptosis and autophagy |
| Lovastatin | Mevacor | Lipophilic (+4.3) | <5 | 40-70 | Cell cycle arrest, induction of apoptosis, suppression of RhoA activity |
| Simvastatin | Zocor | Lipophilic (+4.7) | <5 | 50-80 | Induction of apoptosis through depletion of intracellular cholesterol |
| Pravastatin | Pravacol | Hydrophilic (-0.2) | 17 | 50-70 | Cell cycle arrest at high concentrations |
| Pitavastatin | Livalo | Lipophilic | 80 | ||
| Rosuvastatin | Crestor | Hydrophilic (-0.3) | 20 | Growth inhibition, induction of apoptosis, inhibition of angiogenesis | |
| Fluvastatin | Lescol | Lipophilic (+3.2) | 10-35 | 40-70 | Cell cycle arrest |
| Mevastatin* | Compactin | Lipophilic | |||
| Cerivastatin* | Baycol | Lipophilic | 60 | 50-60 |
*
Not FDA approved as of 2010.