Graphical representation of G4T4G4 DNA and PNA quadruplexes, modified at the 5′- and N-terminals, respectively. (a) an antiparallel hairpin dimeric DNA quadruplex, (b) an antiparallel hairpin dimeric PNA quadruplex, (c) a parallel DNA2-PNA2 hybrid quadruplex, (d) a tetramolecular parallel DNA4 quadruplex, and (e) a dimeric parallel DNA2 quadruplex.