Table I. Altered transcripts associated with xenobiotic metabolism, lipid metabolism, stress response, and apoptosis (twofold change or greater, p < 0.05) in the porcine hepatocytes treated by 0.05 μg/ml T-2[st].
| Gene name | Gene symbol | Genbank accession no. | Fold change | Q value |
|---|---|---|---|---|
| Lipid metabolic processa | ||||
| acyl-Coenzyme A dehydrogenase, long chain | ACADL | NM_213897 | 2.38b | 0 |
| fatty acid desaturase 1 | FADS1 | BG834110 | −4.35 | 0 |
| fatty acid desaturase 2 | FADS2 | CF791131 | −2.78 | 0 |
| fatty acid synthase | FASN | CN166778 | −5.00 | 0 |
| lipase, hepatic | LIPC | BX675010 | 2.05 | 0 |
| low density lipoprotein receptor | LDLR | BX667248 | −4.55 | 0 |
| peroxisome proliferator activated receptor gamma, coactivator 1 alpha | PPARGC-1 | AB106108 | −2.17 | 0 |
| peroxisome proliferator-activated receptor gamma | PPARG | AB097926 | −3.85 | 0 |
| stearoyl-CoA desaturase | SCD | NM_213781 | −2.27 | 0 |
| Phase I reaction | ||||
| carboxylesterase 1C4 | CES1C4 | NM_214246 | 4.57 | 0 |
| cytochrome P450 3A39 | CYP3A39 | NM_214422 | 2.40 | 0 |
| cytochrome P450 3A46 | CYP3A46 | AB052266 | 7.08 | 0 |
| cytochrome P450 C42 | CYP2C42 | Z93098 | 2.33 | 0 |
| cytochrome P450, family 51, subfamily A, polypeptide 1 | CYP51 | NM_214432 | −4.35 | 0 |
| epoxide hydrolase | EPHX1 | NM_214355 | 4.65 | 0 |
| vitamin D3 25-Hydroxylase | CYP2D25 | NM_214394 | −3.13 | 0 |
| Apoptosis and stress response | ||||
| BCL2-associated X protein | BAX | AJ606301 | 4.49 | 0 |
| caspase 1, apoptosis-related cysteine peptidase | CASP1 | NM_214162 | 4.89 | 0 |
| caspase-15 | LOC641352 | BI347127 | 2.82 | 0 |
| 90 kDa heat shock protein | HSP90AA1 | NM_213973 | 3.32 | 0 |
| glutathione peroxidase 1 | GPX1 | NM_214201 | 2.43 | 0 |
a The transcripts were grouped according to their functions.
b Positive values represent up-regulation after treatment; negative values represent down-regulation after treatment.