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In vitro metabolic stability
The percentage of drug remaining was determined by LC-MS/MS. Metabolic stability is presented as half-lives in liver microsomes. Incubations were conducted with 0.5 μM test compounds and 1 mg/ml liver microsomal proteins in the presence of NADPH at 37°C (n = 3, mean ± S.D.).
| Liver Microsomes | Half-Life (min) |
|
|---|---|---|
| ABI-274 | ABI-286 | |
| Human | 21 ± 1 | 44 ± 6 |
| Mouse | 9 ± 1 | 23 ± 2 |
| Rat | 30 ± 2 | 46 ± 4 |
| Dog | 20 ± 3 | 26 ± 2 |
