Fig. 3.

N-1,2-Diol analogs inhibit [³H]5-HT uptake into rat hippocampal synaptosomes. For clarity of presentation, compounds are grouped according to structural similarity of additions to the phenyl rings: standards, lobeline, lobelane, and N-1,2-diol analogs (top left), N-1,2-diol analogs containing 1-naphthyl or 4-biphenyl substituents (top right), N-1,2-diol analogs containing aromatic methoxy or methylenedioxy substituents (bottom left), or N-1,2-diol analogs containing aromatic halogeno substituents (bottom right). Nonspecific [³H]5-HT uptake was determined in the presence of 10 μM fluoxetine. Control (CON) represents specific [³H]5-HT uptake in the absence of analog (0.56 ± 0.06 pmol/mg/min). Symbol inset shows compounds in order from highest to lowest affinity. n = 4 rats/analog.