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. 2011 Oct;339(1):9–23. doi: 10.1124/jpet.111.182873

Fig. 4.

Fig. 4.

Functional characterization of NT5C2 promoter SNPs rs11191612 and rs10748839. A and D, differences in transcription factor binding sites for WT and variant alleles of rs11191612 and rs10748839 identified by Transfac analysis. B and E, luciferase reporter assays comparing transcriptional activation NT5C2-pGL3basic vectors with WT or variant alleles of rs11191612 and rs10748839. Transfection efficiency was normalized to β-galactosidase activity. C and F, representative EMSA gels comparing binding of oligos representing WT and variant alleles of promoter SNPs after incubation with HL60 and HeLa nuclear extracts.