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The effects of varenicline pretreatment (15 min, subcutaneously) on the discriminative stimulus (a and c) and rate-decreasing effects (b and d) of cumulative doses of nicotine in small-dose (left) or large-dose (right) nicotine-trained rats. Dose-effect curves after varenicline pretreatments were averaged across 10 to 12 rats. resp, responses.
