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Transcriptional activation of the wtAhR and mutants F281A and L287A by ANF and MNF. COS-1 cells were transiently transfected and analyzed for activation of AhR-dependent transcription as described in the legend to Fig. 3. L287A mutant AhR agonist activity that was significantly different from the corresponding wtAhR values at p < 0.05 as determined by Student's t test is indicated (*). Results are representative of three independent experiments.
