FIGURE 2.

Motor behavioral analyses of M47 E46K human α-syn transgenic mice. A, representative track of fore (red) and hind (black) paws of a 9-month-old M47 E46K α-syn transgenic mouse. Footprint analysis of walking performance for distance between fore and hind footprints of overlapping steps (B) and stride length (C) showed no significant difference between presymptomatic E46K α-syn transgenic and nontransgenic mice at various ages as indicated. No significance was also observed in assessing motor performance by the wire hang test (D). Data are presented as group means ± S.E. (error bars) and were analyzed by Student's t test; p was set at <0.05 as level of significance.