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Effect of plasmin inhibitors on keratinocyte migration. Human keratinocytes were plated on fibrin matrix and cultivated in medium containing 10% serum in the absence of EGF. After 24 h, the cultures were fixed, and the number of motile cells was counted. (A) Effect of aprotinin (Antagosan, Hoechst Pharmaceuticals). All evidence of motility disappeared at concentrations of 500 kallikrein units/ml. (B) Effect of PAI-1. All motility disappeared at a concentration of 10–15 μg/ml.
